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Item ID: nht00020b   Source ID: 2

Description: Genital Herpes (Herpes Simplex (HSV) –types 1 and 2)

Definition Genital herpes is an infection that causes small, painful, fluid-filled blisters on the genitals, buttocks or thighs. These blisters break open leaving an indented sore or ulcer. These blisters and/or ulcers may occur on other parts of the body, including the mouth, face, or eyes.

Causes Genital herpes is caused by the herpes simplex virus. Although it was previously believed that type 1 was responsible for lesions from the waist up and type 2 for those from the waist down, this has been shown to be incorrect. Genital lesions may be of either type 1 or type 2, and some sources report that currently up to 40% of newly acquired cases of genital herpes are from type 1... More

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Genital Herpes (Herpes Simplex (HSV) –types 1 and 2)

Definition Genital herpes is an infection that causes small, painful, fluid-filled blisters on the genitals, buttocks or thighs. These blisters break open leaving an indented sore or ulcer. These blisters and/or ulcers may occur on other parts of the body, including the mouth, face, or eyes.

Causes Genital herpes is caused by the herpes simplex virus. Although it was previously believed that type 1 was responsible for lesions from the waist up and type 2 for those from the waist down, this has been shown to be incorrect. Genital lesions may be of either type 1 or type 2, and some sources report that currently up to 40% of newly acquired cases of genital herpes are from type 1 virus. The virus enters the body through a break in the skin or through mucous membranes. After the first outbreak of genital herpes, the virus migrates to nerve endings at the base of the spine, and lies dormant until the next outbreak.

The virus is spread through:

An infected mother passing it on to her child during pregnancy or childbirth Fluid from herpes blisters that gets on other parts of the body Sexual contact, including intercourse and oral and anal sex The virus is most contagious when blisters are present. It is also contagious during the 'shedding' stage, before blisters or sores are visible. The virus may also spread when inactive between outbreaks.

Risk Factors A risk factor is something that increases your chance of getting a disease or condition. The strongest risk factor for getting the herpes simplex virus is unprotected sexual contact with a partner infected with the virus.

Once the herpes simplex virus is present in the body, other risk factors can trigger the blisters to form. Often, the exact cause of an outbreak of genital herpes is unknown.

Risk factors for an outbreak of genital herpes in people already infected with the virus include:

Fever Illness or infection Long periods of exposure to sunlight Menstruation Stress Weakened immune system Symptoms Symptoms vary dependent on whether this is the patient’s first (primary) episode or a recurrent episode. The virus remains dormant in between outbreaks and during this period the patient may not have any noticeable symptoms but may still be shedding (releasing) virus and able to spread the virus to a sexual partner. When the virus is active, symptoms also vary and some people still have no symptoms. The frequency of genital herpes outbreaks varies from person to person. Most people have outbreaks at least once per year.

PRIMARY INFECTION – occurs in a patient who is newly exposed to HSV. Although they may have no noticeable symptoms (asymptomatic), many experience a flu-like syndrome which includes fever and muscles aches. The lesions may be genital and/or present on other areas of the body, including the mouth/lips/tongue, and are usually larger in size and number than occurs in repeat or recurrent episodes. The lesions of a primary infection usually resolve within 2 weeks unless they get a second infection with a skin bacteria or fungus in which case they may persist for up to 6 weeks.

RECURRENT INFECTION – represents a reactivation of the herpes virus. This recurrence will vary from patient to patient in terms of severity, duration, and amount of virus shed. In general though, recurrences tend to result in fewer, smaller ulcers which usually last only 3-7 days. Symptoms are usually limited to the area around the blister or ulcer. It is important to remember that viral shedding can occur with or without visible lesions and that this asymptomatic (no symptoms or sores) lesions are currently responsible for over 50% of new infections

Diagnosis The doctor will ask about your symptoms and medical history, and perform a physical exam, particularly of the blisters and/or ulcers. Herpes lesions may look like other infections and may not be immediately visible if inside the urinary tract, vagina or cervix. The doctor may need to open a blister to swab it and send it to the lab or take a blood sample for testing.

Treatment Treatments to ease pain include:

Anti-viral creams and ointments Cool cloths placed on blisters or sores Lukewarm baths Non-prescription pain relief drugs Wearing loose fitting clothes Treatments to speed healing include:

Keeping blisters/sores dry when not bathing Oral anti-viral medications Treatments for bacterial infection of the blisters/sores include:

Antibiotic medications Prevention To prevent the spread of the herpes simplex virus:

Avoid oral sex if your partner has herpes blisters on the mouth or genital area. Avoid sexual contact with an infected partner from the time the partner feels initial symptoms until blisters/sores have completely healed. Avoid touching blisters to prevent spreading to other parts of the body. If you are pregnant and infected with the herpes virus, tell your doctor. Medication given to newborns immediately after birth can decrease the chance that they will be infected. If you have active herpes blisters when it is time to deliver your baby, the doctor may recommend that you deliver by Cesarean section. If your partner is infected, use latex condoms during sex when your partner shows symptoms of genital herpes. Last reviewed: April 2003 by Joan Lingen, MD.

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